Item		Judgmenta	Description (quote from paper, or describe key information)
1. Sequence generation
2. Allocation concealment
3a. Confoundingb	Outcome 1
3b. Confoundingb	Outcome 2
4a. Blinding?	Outcome 1
4b. Blinding?	Outcome 2
5a. Incompl. outcome data addressed?	Outcome 1
5b. Incompl. outcome data addressed?	Outcome 2
6a. Free of selective reporting?	Outcome 1
6b. Free of selective reporting?	Outcome 2
7. Free of other bias?
8. A priori protocol?c
9. A priori analysis plan?d

^aSome items on low/high risk/unclear scale (items 1–2), some on 5-point scale/unclear (items 3–7), some on yes/no/unclear scale (items 8–9). For all items, record ’unclear’ if inadequate reporting prevents a judgment being made.

^bBased on list of confounders considered important at the outset and defined in the protocol for the review (and assessment against worksheet)

^cDid the researchers write a protocol defining the study population, intervention and comparator, primary and other outcomes, data collection methods, etc. in advance of starting the study? N.B. May be outcome specific.

^dDid the researchers have an analysis plan defining the primary and other outcomes, statistical methods, subgroup analyses, etc. in advance of starting the study?