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. 2014 Dec;34(24):4534–4544. doi: 10.1128/MCB.00997-14

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FIG 3 — Epidermal hyperplasia and an abnormal stratum corneum in newborn Lmna^−/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ mice. (A) Hematoxylin and eosin (H&E) staining of skin sections from newborn Lmna^+/+ Lmnb1^Δ/Δ Lmnb2^Δ/Δ, Lmna^+/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ, and Lmna^−/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ mice. In Lmna^−/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ mice, the epidermis (brackets) was thickened (epidermal hyperplasia) with a compressed stratum corneum. Also, nuclei were retained in the stratum corneum (parakeratosis) (yellow arrowheads). The layers of the stratum granulosum and stratum corneum were interspersed (black arrowheads). (B) Accumulation of numerous tiny neutral lipid droplets in the stratum corneum (brackets) of Lmna^−/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ mice. Skin sections from Lmna^+/+ Lmnb1^Δ/Δ Lmnb2^Δ/Δ and Lmna^−/− Lmnb1^Δ/Δ Lmnb2^Δ/Δ mice were stained with BODIPY (green); DNA was visualized with DAPI (red).