TABLE 1.
Group no. | No. in group (no. survived) |
Challenge time (mo) | Vaccine dilution | |
---|---|---|---|---|
Treated | Control | |||
1 | 10 (8) | 2 (0) | 52 | Undiluted |
2 | 9 (9) | 1 (0) | 52 | 1:5 |
3 | 10 (6) | 2 (0) | 52 | 1:10 |
4 | 10 (5) | 2 (1) | 12 | 1:20 |
5 | 10 (4) | 2 (1) | 12 | 1:40 |
6 | 10 (8) | 2 (0) | 12 | 1:10 |
7 | 10 (6) | 2 (1) | 12 | 1:20 |
8 | 10 (9) | 2 (1) | 12 | 1:40 |
9 | 9 (6) | 2 (1) | 30 | 1:10 |
10 | 10 (10) | 2 (0) | 30 | Undiluted |
11 | 8 (8) | 2 (1) | 30 | 1:5 |
12 | 8 (7) | 2 (1) | 30 | 1:20 |
Total | 114 (86) | 23 (7) |
A total of 137 rhesus macaques (Macaca mulatta) were included in the study. The animals were injected intramuscularly with a 0.5-ml human dose of AVA or saline-diluted AVA (treated) or saline (control) at 0, 1, and 6 months, followed by aerosol challenge with spores of B. anthracis Ames strain at month 12, 30, or 52.