TABLE 3.
Variable name | Time point (mo) | Simple logistic regression results |
BBR LASSO | Elasticnet |
Glmnet |
||||
---|---|---|---|---|---|---|---|---|---|
Intercept (P value) | Parameter (P value) | AUC (95% Cl) | LASSO | Elastic net | LASSO | Elastic net | |||
IgG | 6 | 0.8952 (<0.0001) | 1.7332 (<0.0001)a | 0.7724 (0.6956–0.8491) | X | ||||
7 | −0.6569 (0.0582) | 1.0009 (<0.0001)a | 0.7956 (0.7208–0.8703) | X | X | ||||
Last | 0.7105 (0.0015) | 2.1628 (<0.0001)a | 0.8214 (0.7514–0.8914) | • | • | • | • | • | |
TNA | 6 | −1.346 (0.0060) | 1.8551 (<0.0001)a | 0.7416 (0.6689–0.8143) | X | ||||
7 | −1.9889 (0.0006) | 1.0808 (<0.0001)a | 0.7918 (0.7158–0.8678) | X | X | ||||
SI | 2 | −4.9416 (<0.0001) | 1.4900 (<0.0001)a | 0.7860 (0.7086–0.8633) | • | • | • | • | • |
6 | −3.9370 (0.0376) | 1.4369 (0.0111)a | 0.7095 (0.5809–0.8381) | • | • | • | • | • | |
IFNeLi | 6 | −0.3719 (0.3090) | 0.7881 (0.0004)a | 0.7073 (0.6077–0.8068) | X | ||||
R_IL4IFNeLi | 7 | 0.6808 (0.0020) | −0.1508 (0.3684) | 0.5428 (0.4195–0.6661) | X | ||||
IL4e | 1 | −2.0654 (0.5856) | 2.0972 (0.4594) | 0.5149 (0.4790–0.5508) | X | ||||
TNFe | 1 | 3.2168 (0.0787) | −1.4247 (0.1622) | 0.6627 (0.5485–0.7769) | X | ||||
R_IL4IFNm | 7 | 0.6608 (0.0004) | −0.7249 (0.0508) | 0.5829 (0.4844–0.6815) | X | ||||
No. of variables | 3 | 3 | 5 | 3 | 12 | ||||
Variable set identifier | Par_LASSOc | Par_LASSOc | Par_elastic_Elasticnet | Par_LASSOc | Par_elastic_Glmnet |
P value of <0.05 from Wald chi-square test of the parameter estimate.
•, variables that were selected by all five selection methods. X, variables that were selected by 1 or 2 methods.
Parsimonious selections by LASSO in all the packages selected the same variables that were considered one variable set, Par_LASSO, for subsequent analyses.