TABLE 3.

T-cell proliferative responses to B. pertussis antigens

Sample	PT				FHA				PRN				FIM
	n	SIa	Pb	% CMI+c	n	SI	P	% CMI+	n	SI	P	% CMI+	n	SI	P	% CMI+
Pre-primary series	34	0.9, 1.0, 1.2		0	28	0.1, 0.2, 0.3		0	27	1.0, 1.5, 2.5		15	25	0.6, 0.8, 1.0		0
Post-primary series	33	2.5, 3.9, 5.8	<0.001	67	29	0.4, 0.7, 1.5	0.008	7	29	1.9, 3.0, 5.5	0.002	52	24	1.1, 1.3, 1.6	<0.001	12
Prebooster	43	1.2, 1.7, 3.2	0.032	37	34	0.3, 0.6, 1.4	0.984	9	31	1.4, 2.0, 2.8	0.058	19	27	0.8, 1.1, 1.7	1	0
Postbooster	37	1.3, 3.3, 5.1		54	29	0.3, 0.9, 2.1		14	21	1.2, 1.7, 2.5		24	18	0.7, 1.1, 1.5		0

^aSI is presented as median with interquartile range (lower quartile, median, upper quartile).

^bThe magnitudes of T cell proliferative responses were compared between the pre- and post-primary series time points and between the post-primary series and prebooster time points by using the Wilcoxon signed-rank test. A P value of ≤0.05 is considered statistically significant.

^cPercentage of subjects with a positive cell-mediated immune response (i.e., SI ≥ 3).