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. 2014 Dec;21(12):1620–1627. doi: 10.1128/CVI.00598-14

FIG 4.

FIG 4

IL-10 and TGF-β do not affect the frequencies of CD8+ T cells expressing type 1 and type 2 cytokines in filarial infections. (A) Frequencies of CD8+ T cells expressing type 1 and type 2 cytokines following stimulation with BmA, after IL-10 neutralization, in a subset of INF individuals (n = 7). IL-10 neutralization significantly increases the frequency of CD8+ T cells expressing IL-22 and significantly decreases the frequency of CD8+ T cells expressing IL-9. (B) Frequencies of CD8+ T cells expressing type 1 and type 2 cytokines following stimulation with BmA, after TGF-β neutralization, in a subset of INF individuals (n = 7). TGF-β neutralization significantly increases the frequency of CD8+ T cells expressing IL-22 and significantly decreases the frequency of CD8+ T cells expressing IL-9. Antigen-stimulated frequencies are shown as net frequencies, with the baseline levels subtracted. Each line represents a single individual. P values were calculated using the Wilcoxon signed-rank test.