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pBac115 contains thiopeptide biosynthetic (tcl) genes. (A) Plasmid map of pBac115 with annotation based upon results from BLASTx and direct alignments with previously identified tcl genes. (B) Amino acid sequence of the TclE precursor peptide. The asterisk indicates the predicted cleavage site; the core peptide, which undergoes modification to produce the mature thiopeptide, is underlined.
