TABLE 3.

Genes differentially expressed in FLL366 under both anaerobic and hydrogen peroxide stress conditions

Gene ID	Annotation	HPSa		ANb
		Fold change	P value	Fold change	P value
Downregulated
PG_0061	YngK protein	−1.61	0.000426	−1.53	6.7E−17
PG_0195	Rubrerythrin	−2.01	0.002247	−1.66	0.00278
PG_0548	Pyruvate ferredoxin/flavodoxin oxidoreductase family protein	−2.77	0.000341	−1.64	1.5E−09
PG_0682	ABC transporter, permease protein, putative	−1.50	0.019527	−1.67	1.4E−17
PG_0683	ABC transporter, permease protein, putative	−1.75	0.001568	−1.74	1.1E−13
PG_1006	Hypothetical protein PG1006	−1.50	0.006456	−1.75	1.5E−22
PG_1172	Iron-sulfur cluster binding protein, putative	−3.41	0.000149	−1.59	7.2E−08
PG_1173	YkgG family protein	−1.96	0.000406	−1.52	7E−08
PG_1214	Hypothetical protein PG1214	−2.14	0.00121	−1.64	1.8E−22
PG_1392	Rod shape-determining protein RodA, putative	−1.62	0.001405	−1.63	5.5E−14
PG_1393	Penicillin-binding protein 2, putative	−1.59	0.000734	−1.83	3.8E−17
PG_1402	Rhomboid family protein	−1.53	0.003675	−1.63	2.9E−11
PG_1734	Transporter, putative	−1.62	0.003835	−1.66	3.1E−11
PG_1738	Hypothetical protein PG1738	−1.85	0.006191	−1.55	8.7E−13
PG_1778	Hypothetical protein PG1778	−1.51	0.016187	1.55	4.1E−13
PG_1812	2-Ketoisovalerate ferredoxin reductase	−1.20	4.66E−05	−1.57	0.03345
Upregulated under AN but downregulated under HPS conditions
PG_0689	NAD-dependent 4-hydroxybutyrate dehydrogenase	−1.74	0.00621	1.55	1.8E−08
PG_0691	NifU-related protein	−1.52	0.011859	1.50	6E−07
Upregulated
PG_0329	Formiminotransferase-cyclodeaminase-related protein	1.51	0.195903	1.81	4.4E−12
PG_0330	Histone-like family DNA-binding protein	1.50	0.08439	1.72	4.5E−10
PG_0495	Hypothetical protein PG0495	5.57	1.4E−05	2.38	0.00565
PG_0592	50S ribosomal protein L31 type B	1.76	0.014037	1.83	3.3E−16
PG_0612	Hypothetical protein PG0612	2.01	7.83E−05	1.50	3.2E−13
PG_0686	Hypothetical protein PG0686	2.66	0.000614	1.68	1.2E−12
PG_0707	TonB-dependent receptor, putative	2.69	7.8E−05	2.56	5.6E−17
PG_0985	ECF subfamily RNA polymerase sigma factor	3.68	0.000346	1.99	2.8E−16
PG_0986	Hypothetical protein PG0986	4.84	1.61E−05	1.89	5.8E−16
PG_0987	Hypothetical protein PG0987	5.40	1.51E−05	1.83	8.5E−15
PG_1019	Putative lipoprotein	14.88	4.43E−06	2.75	0.02315
PG_1108	Hypothetical protein PG1108	1.61	0.004065	2.13	1E−07
PG_1178	Hypothetical protein PG1178	9.23	1.62E−05	2.82	0.04231
PG_1179	Hypothetical protein PG1179	11.44	4.76E−05	2.53	0.04907
PG_1180	Hypothetical protein PG1180	11.06	1.53E−05	1.86	0.00836
PG_1181	Tetr family transcriptional regulator	4.73	9.09E−05	1.52	0.00481
PG_1236	Hypothetical protein PG1236	4.09	1.43E−06	2.81	2.5E−06
PG_1237	LuxR family transcriptional regulator	4.54	1.08E−05	3.42	3.3E−06
PG_1240	TetR family transcriptional regulator	2.62	0.000192	1.67	7.6E−12
PG_1268	Hypothetical protein PG1268	3.77	0.000276	2.40	7.8E−14
PG_1315	Peptidyl-prolyl cis-trans isomerase SlyD, FKBP-type	1.65	0.007939	2.04	4.5E−11
PG_1316	Hypothetical protein PG1316	1.52	0.025092	1.84	9.1E−11
PG_1497	Histone-like family DNA-binding protein	1.65	0.069685	2.12	1.1E−09
PG_1551	HmuY protein	4.82	0.000105	2.04	0.00261
PG_1552	TonB-dependent receptor HmuR	4.26	0.000935	2.17	0.00173
PG_1553	CobN/magnesium chelatase family protein	4.41	3.18E−05	2.25	0.02276
PG_1625	Hypothetical protein PG1625	4.72	2.63E−06	1.78	1.8E−08
PG_1659	Hypothetical protein PG1659	1.76	0.009558	1.89	3.2E−20
PG_1755	Fructose-1,6-bisphosphate aldolase	1.75	0.000758	1.80	1E−10
PG_1798	Immunoreactive 46-kDa antigen PG99	3.07	0.000153	1.61	3.1E−06
PG_1856	Cytidine/deoxycytidylate deaminase family protein	3.22	0.000332	1.83	0.00143
PG_1857	Hypothetical protein PG1857	5.19	0.000125	1.69	0.00514
PG_1858	Flavodoxin FldA	4.26	1.95E−05	2.65	0.10882

^aHPS, hydrogen peroxide stress.

^bAN, anaerobic conditions.