FIG 4.

Cytokine, chemokine, and growth factor changes in BALB/c mice infected with MARV/Ang or MARV/Ang-MA. Plasma samples were collected at the indicated time points from individual BALB/c mice (4 to 6 per time point) infected with 2,000× LD₅₀ MARV/Ang-MA (red) or the equivalent MARV/Ang (black) dose. The following parameters were presented: FGF-basic (A), gamma interferon (IFN-γ) (B), interleukin-1β (IL-1β) (C), IL-2 (D), IL-4 (E), IL-5 (F), IL-6 (G), IL-10 (H), IL-12 (I), IL-13 (J), IL-17 (K), IFN-γ induced protein 10 (IP-10) (L), keratinocyte chemoattractant (KC) (M), monocyte chemoattractant protein 1 (MCP-1) (N), monokine induced by IFN-γ (MIG) (O), macrophage inflammatory protein 1α (MIP-1α) (P), tumor necrosis factor α (TNF-α) (Q), and vascular endothelial growth factor (VEGF) (R). The data are expressed as means ± standard errors. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (significance was determined by comparing data for MARV/Ang and MARV/Ang-MA at same time points).