Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Models for HIV-1/SIV Vif and BIV Vif recruitment of various CRL E3 ligase complexes. (Top) HIV-1/SIV Vif recruits CUL5, ELOB/C, CBF-β, and RBX2 to form an A3 targeting CRL5 E3 ligase. HIV-1/SIV Vif utilized the BC box to interact with ELOB/C and HCCH to interact with CUL5. (Bottom) BIV Vif recruits CUL2, ELOB/C, and RBX1, but not CUL5 or CBF-β, to form an active CRL2 E3 ligase. BIV Vif utilized the BC box to interact with ELOB/C and CCHC as well as YI motifs to interact with CUL2.
