TABLE 1.
Tissue cytokine profiles in EV71-infected mouse models and human patients
| Model or patient groupa | Tissue | Cytokine profile |
|---|---|---|
| NOD/SCID mice | Spleen | IL-23, IL-10, TNF-α, IFN-α, MCP-1 |
| Muscle | IFN-γ, IL-10, IP-10, IFN-α, MCP-1, IL-1β, IL-12, TNF-α, MIP2, VEGFA | |
| Brain | IFN-γ, IL-10, IP-10, IL-6, MCP-1, IL-1β, IL-12, IFN-α, MIP2, VEGFA | |
| Spinal cord | IFN-γ, IL-10, IP-10, IL-6, MCP-1, IL-23, IL-17F, IFN-α, MIP2 | |
| stat-1 KO mice | Muscle | IFN-γ, IL-10, IFN-α |
| Spinal cord | IL-17F, IFN-α, IP-10, IL-6 | |
| AG-129 mice | Serum | IFN-γ, IL-10, TNF-α, IL-6, MIP2, IL-1β |
| h-SCARB2-Tg mice | Brain and spinal cord | CCL-3, TNF-α, IP-10, IL-6 |
| Patients with pulmonary edema | Serum and cerebrospinal fluid | IFN-γ, IL-10, IP-10, IL-6, MCP-1, IL-1β, TNF-α, Mig, IL-13 |
a
One-week-old NOD/SCID or stat-1 KO mice were infected i.p. with 108 PFU of EV71. Mice were sacrificed on 4, 8, and 11 dpi. Various tissues from the spleen, muscle, brain, and spinal cord were dissected and homogenized, and tissue cytokines were measured with a Luminex multiplex kit. Experimental results are shown in Fig. S3 and S4 in the supplemental material. See reference 12 for AG-129 mice, reference 17 for h-SCARB2-Tg mice, and reference 26 for patients with pulmonary edema.