TABLE 4.
Neutralization potencies of serotype-specific human MAbs in two different cell lines
| Serotype specificity | MAb | EC50 (μg/ml)a in: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| U937 cells expressing DC-SIGN |
Vero-81 cells |
||||||||
| DENV1 | DENV2 | DENV3 | DENV4 | DENV1 | DENV2 | DENV3 | DENV4 | ||
| DENV1 | 1F4 | 0.1 | > | > | > | 0.02 | > | > | > |
| 4L5 | 1.3 | > | > | > | 0.05 | > | > | > | |
| DENV2 | 1L12 | > | 0.4 | > | > | > | 0.05 | > | > |
| 3F9 | > | 0.03 | > | > | > | 0.003 | > | > | |
| 4J23 | > | 4.0 | > | > | > | 0.08 | > | > | |
a
EC50s of 1.0 to 10.0 μg/ml are shown. EC50s of <1.0 μg/ml are shown in bold, and EC50s of <0.1 μg/ml are shown in bold italics. >, neutralization was not detected when the MAb was tested at concentrations as high as 10 μg/ml.