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. 2014 Nov;88(21):12777–12792. doi: 10.1128/JVI.01814-14

FIG 5.

FIG 5

Acute SVV infection induces robust proliferation of CD4 and CD8 T cells in the lungs. The frequencies (means ± SEM) of central memory (CM; CD95+ CD28+ CCR7+), transitional effector memory (TEM; CD95+ CD28+ CCR7−), and effector memory (EM; CD95+ CD28− CCR7−) subsets in CD4 (A, B) and CD8 (C, D) T cells in BAL cells (A, C) and PBMC (B, D) were measured by flow cytometry. Proliferation (mean ± SEM) of T cell subsets was measured by the expression of Ki67 in CD4 (E, F) and CD8 (G, H) T cells in BAL cells (E, G) and PBMC (F, H) (+, P < 0.05; ++, P < 0.01; +++, P < 0.001; ++++, P < 0.0001 for CM) (#, P < 0.05; ##, P < 0.01; ###, P < 0.001; ####, P < 0.0001 for TEM) (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 for EM).