FIG 8.

Acute SVV infection results in upregulation of granzyme B in CD4 and CD8 T cell subsets in the lungs. The frequencies (means ± SEM) of granzyme B-positive T cells within CM, TEM, and EM subsets of CD4 (A and B) and CD8 (C and D) T cells were assessed by flow cytometry in BAL cells (A and C) and PBMC (B and D) (++, P < 0.01for CD4 CM) ($$$$, P < 0.0001 for CD4 TEM) (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 for CD4 EM) (&&, P < 0.01 for CD8 CM) (X, P < 0.05; XX, P < 0.01; XXX, P < 0.001; XXXX, P < 0.0001 for CD8 TEM) (#, P < 0.05; ##, P < 0.01; ###, P < 0.001; ####, P < 0.0001 for CD8 EM).