TABLE 1.
Vaccine constructs
| Vaccine construct | Description | Dose and route | Source or reference |
|---|---|---|---|
| VREP-OVA | Viral replicon particle (VREP) encoding SFV nsP1-nsP4 and model antigen OVA | 103, 104, 105, 106, 107, or 108 IU, s.c. | 30 |
| DREP-OVA | DNA replicon (DREP) encoding SFV nsP1-nsP4 and model antigen OVA | 2 μg, i.d., + EP | 38 |
| CHIKV | Wild-type CHIKV | 105 PFU, s.c. | 27 |
| DREP-Env | DREP encoding CHIKV nsP1-nsP4 and E1-E3 (Env) | 10 μg, i.d., + EP | Unpublished dataa |
| p62-E1 | Recombinant CHIKV E1-E3 (p62-E1) protein | 1 μg, i.m. | 28 |
| MVA-CHIKV | Recombinant MVA encoding CHIKV capsid and E1-E3 | 107 PFU, i.p. | 20 |
a
D. Hallengärd, F.-M. Lum, B. M. Kümmerer, A. Lulla, V. Lulla, J. García-Arriaza, J. K. Fazakerley, P. Roques, R. Le Grand, A. Merits, L. F. P. Ng, M. Esteban, and P. Liljeström, unpublished data.