FIG 6.

High SeV dose increases pathogenesis and IFN-β induction but not subsequent virus replication in wt mice. Survival of wt (A) and IFNAR^−/− (B) mice after infection with medium or high SeV dose. (C) Infectious SeV titers in lungs of wt, Ifit2^−/−, and IFNAR^−/− mice (n = 3 to 5) at 5 days after infection with medium or high SeV dose. (D) IFN-β mRNA expression in lungs of wt, Ifit2^−/−, and IFNAR^−/− mice (n = 4 to 6) at 2 days after SeV infection (medium or high dose), measured by real-time RT-PCR. Data shown panels A and B are derived from data depicted in Fig. 1B, C, and E. Data for medium dose infection in panels C and D are partially derived from data shown in Fig. 2C and 3C, respectively. Asterisks indicate statistical significance; n.s., not significant.