FIG 8.

Effect of HERV-K(HML2) Env-Rec on several primate Tetherin proteins. HERV-K(HML2) Env-Rec was tested for its ability to antagonize several primate Tetherin proteins as described in the legend to Fig. 2A. For each Tetherin and antagonist tested, the relative viral titer measured with 25 ng of Tetherin is represented (100% corresponds to the value measured in the absence of Tetherin), with the average fold increase compared to the “None” condition indicated above each antagonist. Statistical tests were done as described in the legend to Fig. 3A using 9 independent experiments. A phylogenetic tree of primates is presented (top). The arrows indicate amplification bursts of HERV-K(HML2) elements during primate evolution (from reference 8) (OGM and NWM, Old and New World monkeys, respectively).