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Body weight changes and survival curves for mice challenged with lethal doses of PR8. Eight mice per group were intranasally infected with 100 MLD50 of PR8 2 weeks after their final vaccination. Body weights were measured (A) and survival rate was monitored (B) for 14 days after infection. Open triangles, mice inoculated with medium; open squares, mice inoculated with HA-KO/GFP virus; closed circles, mice inoculated with HA-KO/PspA virus.
