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. 2014 Nov;88(22):12968–12981. doi: 10.1128/JVI.01816-14

FIG 5.

FIG 5

Epitope specificity of the bNAb activity in subject VC20013. (A and B) Anti-MPER activity in subject VC20013 from 0.51 year postinfection (A) and 2.6 years postinfection (B) was measured against the HIV-2/HIV-1 MPER chimeras. The region of the MPER that has been inserted into the HIV-2 backbone is noted in parentheses in the legend in panel B (WT, wild type; N-term, N terminus). (C and D) Effects of the MPER escape mutations in modulating neutralization sensitivity to VC20013 plasma from 2.6 YPI. The escape mutations are K677N in TRO.11 (C) and H677N in SC422661.8 (D). WT, wild type (unmodified sequence).