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Anti-MPER NAbs mediate autologous neutralization in subject VC20013. The MPER mutations at residue 677 were inserted into autologous isolates from subject VC20013. The escape mutation K677N was inserted into a neutralization-sensitive isolate (A), which resulted in a reduction in neutralization. The reversion mutation N677K was inserted into two neutralization-resistant VC20013 isolates (B and C), which resulted in an increased ability to neutralize the virus. WT, wild type.
