FIG 2.

Effect of timing of antilatency drug treatment relative to ART. (A) We assume that antilatency drugs increase the rate of activation of latently infected cells. (B) The effect of antilatency drugs on the activation rate can be either multiplicative (activation rate is multiplied by a dose-dependent factor) or additive (activation rate increases by a dose-dependent amount). (C and D) ART starts at time = 0 (black vertical line). Antilatency drugs are given for 3 days either just before ART (pink interval), at the start of ART (purple interval), or after more than a week of ART when the viral load is close to undetectable (green interval). A black line represents the set point viral load (upper panel) and the stable latently infected cell pool (lower panel) in the untreated infection. A red line shows the effect of an activator given just before the start of ART. A purple line shows the effect of activator given at the start of ART. A green line represents ART with the activator given late during ART. The parameters for the untreated infection were the same as in Fig. 1. During ART, β = 0; multiplicative effect, κ = 3; additive effect, κ = 0.5.