TABLE 1.

Monoclonal antibodies used in competition ELISAs

MAb	Protein targeted	Conformation dependence	Species	Critical binding residuesa	Interaction targeted	Neutralization potencyb	Reference
AP33	E2	No	Mouse	413, 415, 418, 420	CD81	2a (HCVcc); 1a, 1b, 2a, 3a, 4a, 5a, 6a (HCVpp)	23 – 25
HC33.4	E2	No	Human	413, 418, 420, 421	CD81	1a, 2a, 3a, 4a, 5a, 6a (HCVcc)	28
HC84.26	E2	Yes	Human	429, 441, 442, 446, 616	CD81	1a, 2a, 3a, 4a, 5a, 6a (HCVcc)	27
1:7	E2	Yes	Human	415, 417, 484, 491, 523, 525, 526, 527, 529, 530, 533, 535, 540	CD81	2a (HCVcc); 1a, 1b, 2a, 3a, 4a, 5a, 6a (HCVpp)	26
AR3B	E2	Yes	Human	412, 416, 418, 423, 424, 523, 525, 530, 535, 540	CD81	2a (HCVcc); 1a, 1b, 2a, 2b, 4, 5, 6 (HCVpp)	15
AR4A	E1E2	Yes	Human	201, 204, 205, 206, 487, 657, 658, 692, 698	Unknown	1a, 1b, 2a, 3a, 4a, 5a, 6a (HCVcc); 1a, 1b, 2a, 2b, 2i, 2x, 3a, 4, 5, 6 (HCVpp)	16
AR5A	E1E2	Yes	Human	201, 204, 205, 206, 639, 657, 658, 665, 692	Unknown	1a, 2a, 4a, 5a, 6a (HCVcc); 1a, 1b, 4, 5, 6 (HCVpp)	16
IGH526	E1	Untested	Human	313–327	Unknown	1a, 1b, 2a, 4a, 5a, 6a (HCVpp)	31
A4	E1	No	Mouse	197–207	None	NA	29, 30

^aAll amino acid numbering is based on the H77c isolate strain (GenBank accession number AF009606) as specified by international consensus (66).

^bHCVcc, cell culture-derived HCV; HCVpp, HCV retroviral pseudoparticles; NA, not applicable.