TABLE 4.
Validation of the study approach to link pig-tailed macaque MHC-I haplotypes with CTL escape mutations by using previously defined CTL responses restricted by the Mane-A1*084 allele
| Protein | Epitope | Region of epitope within protein | No. of Mane-positive mutation-positive animals/total no. of Mane-positive animals | No. of Mane-negative mutation-positive animals/total no. of Mane-negative animals | P value (two-tailed) | Amino acid change | Escape motifa |
|---|---|---|---|---|---|---|---|
| Gag | KP9 | 164–172 | 11/16 | 0/28 | 5.7E−07 | K → R | KRFGAEVVP |
| Tat | KSA10 | 87–96 | 6/16 | 0/28 | 1.1E−03 | A → T | KKAKTNTSSA |
| KSA10 | 87–96 | 6/16 | 0/28 | 1.1E−03 | S → T or S → P | KKAKANTSTA or KKAKANTSPA | |
| KSA10 | 87–96 | 5/16 | 0/28 | 4.0E−03 | A → T | KKTKANTSSA | |
| Tat | KVA10 | 114–123 | 9/16 | 0/28 | 1.6E−05 | K → E | EKETVEKAVA |
| KVA10 | 114–123 | 7/16 | 0/28 | 3.0E−04 | K → E | KEETVEKAVA |
a
The mutated amino acids are in boldface and underlined.