TABLE 3.
Fold changes in gene expression in SPD1078M relative to D39 in different tissues
| Type of gene and gene namea (locus tag) | Mean fold change in gene expression (SD) in: |
||
|---|---|---|---|
| Nasopharynx | Lungs | Blood | |
| Metabolic genes | |||
| adh (SPD_0265) | 2.03 (0.41) | 1.5 (0.22) | 2.38 (0.83) |
| adh (SPD_1126) | 0.52 (0.23) | 0.94 (0.06) | 0.77 (0.08) |
| adh (SPD_1834) | 4.19 (0.4) | 3.71 (0.34) | 5.15 (1.24) |
| adh (SPD_1865) | 2.3 (0.47) | 1.38 (0.32) | 1.55 (0.31) |
| ldh (SPD_1078) | 0.42 (0.02) | 0.01 (0.15) | 0.43 (0.02) |
| spxB (SPD_0636) | 1.85 (0.79) | 4.46 (0.63) | 1.33 (0.18) |
| pflB (SPD_0420) | 4.25 (0.52) | 2.72 (0.3) | 6.52 (0.6) |
| Virulence genes | |||
| bgaC (SPD_0065) | 0.66 (0.29) | 1.27 (0.42) | 1.4 (0.45) |
| cps2H (SPD_0323) | 0.94 (0.44) | 0.75 (0.19) | 0.32 (0.09) |
| comA (SPD_0049) | 0.38 (0.18) | 0.07 (0.02) | 0.05 (0.01) |
| hyl (SPD_0287) | 1.45 (0.19) | 0.78 (0.22) | 1.24 (0.11) |
| nanA (SPD_1504) | 1.23 (0.36) | 1.97 (0.48) | 1.89 (0.68) |
| ply (SPD_1726) | 1 (0.38) | 0.72 (0.21) | 0.94 (0.27) |
a
Gene names: adh, alcohol dehydrogenase; ldh, lactate dehydrogenase; spxB, pyruvate oxidase; pflB, pyruvate formate lyase; bgaC, β-galactosidase C; cps2H, polysaccharide polymerase; comA, competence factor transporting ATP-binding protein; hyl, hyaluronate lyase; nanA, neuraminidase A; ply, pneumolysin.