FIG 6.

Photomicrography of organs from golden hamsters infected with different Leishmania (Viannia) braziliensis concentrations (10⁴, 10⁵, and 10⁶ parasites) at 105 days postinfection. The following are displayed: a localized dermal granuloma that is representative of a 10⁴ parasite-infected animal (hematoxylin and eosin; ×10 magnification) (A), a dermal spread granulomatous reaction that is representative of a 10⁶ parasite-infected animal (arrow, necrosis; arrowhead, Schaumann bodies) (hematoxylin and eosin; ×20 magnification) (B), macrophage vacuoles with amastigotes (arrow) inside a dermal granuloma of a 10⁶ parasite-infected animal (hematoxylin and eosin; ×100 magnification) (C), Schaumann bodies inside a dermal granuloma (arrows) of a 10⁶ parasite-infected animal (hematoxylin and eosin; ×10 magnification) and Schaumann bodies inside a dermal multinucleated giant cell of a 10⁶ parasite-infected animal (inset, ×40 magnification) (D), granulomas in the spleen parenchyma (arrows) (hematoxylin and eosin; ×10 magnification) that are representative of macroscopic splenic nodules of a 10⁶ parasite-infected animal (inset, arrowhead) (E), and splenic vacuolated macrophages that contain Leishmania, which are representative of a 10⁶ parasite-infected animal (arrow) (hematoxylin and eosin; ×100 magnification) (F).