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. 2014 Nov;82(11):4458–4465. doi: 10.1128/IAI.01897-14

FIG 5.

FIG 5

TACE is involved in hBD-3 induction by A. baumannii on epithelial cells. (A) Specific siRNA transfection significantly reduced the expression of TACE (P < 0.01) and Duox1 (P < 0.05). (B) TACE knockdown resulted in a significant loss of hBD-3 induction (P < 0.05) on A. baumannii-challenged oral epithelial cells, while Duox1 silencing resulted in an increase in the level of hBD-3 induction (P > 0.05). (C) The specific ADAM17 inhibitor TAPI-1 significantly reduced hBD-3 induction (P < 0.01). The ADAM10 inhibitor GI254023X (GI) had no effect on A. baumannii-stimulated hBD-3 induction. The results shown are the means of three independent experiments ± SDs. Cont, control; Neg, negative siRNA transfected; siRNA, specific siRNA transfected. **, P < 0.01; *, P < 0.05.