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Pb2- and F4-specific CD8+ T cells play a synergistic role in damaging the BBB. (A) Schedule of the folic acid assay protocol. Numbers in parentheses denote hours postinfection. Convalescent mice were injected intravenously (i.v.) with both Pb2 and F4 peptides three times and subsequently challenged i.v. with folic acid. (B) Mouse survival 1 h after the second folic acid injection was recorded. P = 0.0391, Fisher's exact test.
