FIG 7.

Comparison of immune responses to conserved epitopes in rabbits immunized with individual or combined antigens. Constant concentrations of sera raised against a single wt antigen or combined wt antigens were allowed to interact with immobilized AMA1 in the presence of increasing concentrations of soluble protein. The average residual binding calculated from at least two independent experiments when 3D7 (A) or FVO (B) AMA1 was the target antigen is shown for each rabbit. The means ± standard errors of the means of data for each immunization group are shown. *, P < 0.05, determined by a Mann-Whitney test (one tailed) comparing each single-antigen immunization group with the combined-wt-antigen immunization group.