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Possible models for C. perfringens type A FP and AAD or SD suggested by the current in vitro results. (A) C. perfringens type A FP does not require NanI production because strains are quickly removed from the intestines by diarrhea. (B) C. perfringens type A AAD or SD does involve NanI production, which may promote adherence and colonization, as required for chronic diarrhea.
