TABLE 4.
Population pharmacokinetic parameters of ciprofloxacin and bootstrap results
| Parametera | Full data set |
Bootstrap |
||
|---|---|---|---|---|
| Final estimate | RSE (%) | Median | 5th–95th percentile | |
| V1 (liters) | ||||
| V1 = θ1 × (CW/1955) | ||||
| θ1 | 1.97 | 17.7 | 1.82 | 0.78–2.59 |
| V2 (liters) | ||||
| V2 = θ2 × (CW/1955) | ||||
| θ2 | 1.93 | 21.9 | 1.97 | 1.38–3.02 |
| Q (liters/h) | ||||
| Q = θ3 × (CW/1955)0.75 | ||||
| θ3 | 2.5 | 32.6 | 2.62 | 1.02–5.41 |
| CL (liters/h) | ||||
| CL = θ4 × (CW/1955)0.75 × Fage × RF × Finotrope | ||||
| θ4 | 0.366 | 6.0 | 0.365 | 0.323–0.407 |
| Fage = (GA/27.9)θ5 × (PNA/27)θ6 | ||||
| θ5 | 2.11 | 11.9 | 2.09 | 1.60–2.57 |
| θ6 | 0.494 | 10.8 | 0.492 | 0.386–0.606 |
| RF = EXP[(CREA-42) × θ7] | ||||
| θ7 | −0.00335 | 46.0 | −0.00331 | −0.00753 to −0.00063 |
| Finotrope | ||||
| θ8 | 0.708 | 10.9 | 0.719 | 0.572–0.869 |
| Interindividual variability (%) | ||||
| V1 | 48.1 | 63.6 | 49.6 | 26.2–77.2 |
| V2 | 49.3 | 68.3 | 51.2 | 15.8–76.9 |
| CL | 33.2 | 19.9 | 31.3 | 25.3–37.4 |
| Interoccasion variability (%) | ||||
| CL | 16.4 | 55.6 | 16.6 | 9.2–26.2 |
| Residual variability (%) | 19.3 | 28.2 | 18.7 | 14.8–23.1 |
a
V1, central volume of distribution; V2, peripheral volume of distribution; Q, intercompartment clearance; CL, clearance; RF, renal function; CW, current weight in grams; Finotrope, scaling factor applied for patients coadministered with inotropic agents; CREA, serum creatinine concentration in μmol/liter; GA, gestational age in weeks; PNA, postnatal age in days. In our population, 1,955 g, 27.9 weeks, 27 days, and 42 μmol/liter were the median current weight (at the day of the study), gestational age, postnatal age, and serum creatinine concentration values, respectively.