FIG 2.
Adjusted total voriconazole trough concentrations (VTCs) based on plasma albumin concentrations (HPA), total bilirubin plasma concentrations (Bilitot), and measured VTCs. VTC = total voriconazole trough concentration (mg/liter). Adjusted VTCs were calculated with the following formula: adjusted VTC = [(100 − VRC PPB)/100] × measured VTC × 2 (where VRC PPB = 30.5015 + 0.668 × HPA − 0.1867 × Bilitot, based on the multivariate analysis of the combined data set of plasma from ICU patients treated with VRC and plasma from ICU patients not treated with VRC, spiked with 1.5, 2.9, and 9 mg/liter of VRC. Solid diagonal lines represent adjusted VTCs for measured VTCs ranging from 3.5 to 6 mg/liter, when Bilitot equals 1 mg/dl. Dotted diagonal lines represent adjusted VTCs for measured VTCs ranging from 3.5 to 6 mg/liter, when Bilitot equals 10 mg/dl. Solid horizontal line A represents an upper limit of 5.5 mg/liter for total VTCs associated with a relatively low probability of toxicity. Dashed horizontal line B represents an upper limit of 4 mg/liter for total VTCs associated with a relatively low probability of toxicity. VRC, voriconazole.