TABLE 2.
Estimated population parameters
| Parameter and modela | Mean | Median | SD |
|---|---|---|---|
| Standard model | |||
| SCL (liters/h) | 0.396 | 0.279 | 0.347 |
| Vc (liters) | 4.259 | 2.592 | 3.597 |
| Kcp (h−1) | 3.344 | 0.434 | 7.742 |
| Kpc (h−1) | 4.424 | 0.252 | 9.742 |
| Linear model | |||
| SCLslope (liters/h/kg) | 0.023 | 0.019 | 0.010 |
| Vc (liters) | 4.138 | 2.282 | 4.143 |
| Kcp (h−1) | 3.876 | 0.474 | 8.156 |
| Kpc (h−1) | 3.994 | 0.292 | 8.930 |
| Allometric model | |||
| SCLstd (liters/h/70 kg) | 0.045 | 0.040 | 0.020 |
| Vc (liters) | 3.447 | 1.975 | 3.579 |
| Kcp (h−1) | 4.897 | 0.564 | 9.054 |
| Kpc (h−1) | 4.227 | 0.228 | 9.638 |
| Standard for adults | |||
| SCL (liters/h) | 1.166 | 1.097 | 0.376 |
| Vc (liters) | 7.925 | 7.669 | 1.849 |
| Kcp (h−1) | 1.179 | 1.158 | 0.449 |
| Kpc (h−1) | 0.154 | 0.155 | 0.087 |
a
SCL (linear model) = SCLslope × weight; SCL (allometric model) = SCLstd × ([weight/70]0.75); Vc, volume of distribution in central compartment; Kcp, first-order rate constant from the central to peripheral compartment; Kpc, first-order rate constant from peripheral to central compartment.