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Final observed and model-predicted probabilities of any treatment-emergent adverse event (AE) versus day 1 AUC(0–24), by region. Lines represent the model-based predicated probabilities of any treatment-emergent adverse event. Symbols represent the median day 1 fAUC(0–24) and associated observed probabilities. Hash marks near the x axis represent the individual day 1 fAUC(0–24) for patients with any treatment-emergent adverse event. N., North; L., Latin; NZ, New Zealand.
