TABLE 6.
Parameter estimates and standard errors from the final logistic regression model for the probability of any treatment-emergent adverse event
| Parameter | Final parameter estimatea |
|
|---|---|---|
| Typical value | % SEM | |
| Logit for placebo in North America, Latin America, and Australia/New Zealand | −1.0487 | 26.0 |
| Logit for slope of day 1 AUC(0–24) (ng · h/ml) | 4.0E−05 | 32.5 |
| Additive shift for Europe | −1.4281 | 16.1 |
| Additive shift for South Africa | −1.3353 | 30.0 |
a
The minimum value of the objective function was 1017.752. The Hosmer-Lemeshow goodness-of-fit chi-square value was 7.6302 (P = 0.4704). The C statistic was 0.652 (the C statistic, a global measure of goodness of fit for logistic regression, measures how well a model discriminates subjects having an event from subjects not having the same event).