FIG 2.

Dose response of BCX4430 in YFV-infected hamsters. Data represent effect of treatment with different doses of BCX4430 on survival (A), mean percent weight change between 3 and 6 dpi (B), serum ALT level (6 dpi) (C), and serum virus titer (4 dpi) (D) of hamsters infected with YFV. Treatment was administered i.p. BID, beginning 4 h before virus challenge and continuing for 7 days. The dashed line in panel D represents the limit of detection. ***, P < 0.001, **, P < 0.01, and *, P < 0.05, compared with vehicle treatment.