TABLE 2.
Disease parameters of surviving and nonsurviving hamsters treated with BCX4430 4 h prior to or 1 day after secondary virus challenge compared with untreated naive animals after primary virus challenge
| Virus challenge, outcome | No. of animals | Disease parameter (mean ± SD) |
||||
|---|---|---|---|---|---|---|
| Weight change between 3 and 6 dpi (g) | Serum ALT at 6 dpi (IU/liter) | Serum AST at 6 dpi (IU/liter) | Serum virus titer at 4 dpi (CCID50/ml) | Neutralizing Ab titera | ||
| Secondary, survived | 17 | 1.5 ± 6.7 | 90 ± 64 | 100 ± 128 | 2.7 ± 1.8 | 164 ± 137 |
| Secondary, did not survive | 3 | − 16.0 ± 3.1b | 227 ± 31c | 364 ± 48c | 4.9 ± 1.5 | <10 ± 0.0 |
| Primary, survived | 1 | 0.0 ± 0.0 | 63 ± 0.0 | 63 ± 0 | 4.7 ± 0.0 | <10 ± 0.0 |
| Primary, did not survive | 5 | − 12.0 ± 7.5 | 209 ± 52 | 312 ± 95 | 4.4 ± 1.9 | <10 ± 0.0 |
a
Neutralizing antibody titer present prior to primary or secondary virus challenge.
b
P < 0.001 compared with values from animals that survived secondary challenge.
c
P < 0.01 compared with values from animals that survived secondary challenge.