TABLE 1.
In vitro interactions by FIC indices of ISA in combination with MFG or AMB against different mold isolatesa
| Isolate (strain) | FIC index (median [range]) |
|
|---|---|---|
| ISA-MFG | ISA-AMB | |
| Aspergillus fumigatus (4215) | 0.75 (0.51–1.06) | 1.5 (0.53–2.5) |
| Aspergillus flavus (10B) | 0.59 (0.51–1.007) | 1.5 (0.14–2.25) |
| Aspergillus terreus (95644) | 0.625 (0.31–1.015) | 1.18 (0.14–2.12) |
| Fusarium oxysporum species complex (34) | 1.015 (0.507–1.5) | 1.37 (1.004–2.5) |
| Fusarium solani species complex (26) | 1.06 (1.007–1.5) | 1.06 (1–2.5) |
| Cunninghamella bertholletiae (182) | 0.59 (0.52–2) | 1.007 (0.5–2.12) |
| Lichtheimia corymbifera (187) | 0.75 (0.5–2.5) | 1.12 (0.56–2.5) |
| Mucor circinelloides (234) | 1.06 (1–1.5) | 1 (0.5–1.24) |
| Rhizopus microsporus (230) | 1.06 (1–1.5) | 1.03 (0.5–2.1) |
| Rhizopus oryzae (98) | 1.06 (1–1.5) | 1.09 (0.56–2.25) |
| Scedosporium apiospermum (142) | 0.28 (0.12–1) | 1.06 (0.5–1.25) |
a
FIC, fractional inhibitory concentration; ISA, isavuconazole; MFG, micafungin; AMB, amphotericin B deoxycholate.