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Stage-specific inhibition of P. falciparum by chlorotonil A. Giemsa-stained thin blood smears of synchronous ring (A), trophozoite (B), and schizont (C) stages. Shown are P. falciparum 3D7 parasites after different incubation times (8, 24, and 40 h) with chlorotonil A and artesunate (ring and trophozoite stages) and epoxomicin and artesunate (schizont stage) at the indicated concentrations compared to those of the drug-free control.
