. 2014 Nov;58(11):6913–6919. doi: 10.1128/AAC.03267-14

TABLE 2.

Phenotypic and genotypic data for the 18 Enterobacteriaceae and 2 P. aeruginosa isolates utilized during the in vivo efficacy studies^a

External isolate no.	CAIRD^a isolate no.	Modal MIC (μg/ml) for^b:			β-Lactamase genotype(s)	Isolate(s) utilized in efficacy study^c
External isolate no.	CAIRD^a isolate no.	CAZ-AVI	CAZ	Meropenem	β-Lactamase genotype(s)	CAZ-AVI I⁻	CAZ I⁻	CAZ-AVI, CAZ I⁺
NA^d	P. aeruginosa 22	4	64	16	ND^e	X
3610	P. aeruginosa 1388	8	128	>8	AmpC^f	X
853469	S. marcescens 80	8	8	>8	AmpC	X	X
3083	S. marcescens 82	8	64	≤0.125	ND	X	X
845662	K. pneumoniae 479	8	>128	>8	SHV-11, KPC-3, OXA-9^g	X	X	X
864091	K. pneumoniae 486	8	>128	>8	SHV-11, KPC-2, OXA-9,^g TEM-1	X	X
249	K. pneumoniae 496	8	>128	>8	KPC-3, SHV-12, TEM-1, OXA-9^g	X
2930	E. cloacae 77	8	>128	0.5	ND	X	X	X
871361	E. aerogenes 50	8	>128	0.5	ND	X	X	X
845664	K. pneumoniae 480	16	>128	>8	SHV-11, KPC-3, TEM-1	X	X	X
867822	K. pneumoniae 487	16	>128	>8	SHV-11, KPC-3, OXA-9,^g TEM-1	X	X	X
883540	K. pneumoniae 493	16	>128	0.25	SHV-11, CTX-M-15, OXA-1, OXA-48, TEM-1	X	X	X
847537	K. oxytoca 87	16	>128	>8	ND	X	X	X
847750	E. cloacae 74	16	>128	0.25	AmpC, OXA-1, OXA-9, PER-2, TEM-1	X
43399	E. cloacae 78	16	>128	8	ND	X	X	X
ARC3726	P. stuartii 58	16	>128	0.0625	AmpC, SCO-1, ACC-4, TEM-1 (partial)	X
869917	K. pneumoniae 489	32	>128	0.0625	SHV-11, TEM-1, OXA-1, CTX-M-15, ACC-4	X	X	X
43475	K. pneumoniae 497	32	64	2	ND	X	X
875448	E. aerogenes 51	32	>128	0.125	AmpC, CTX-M-27	X	X	X
856743	P. mirabilis 19	32	64	4	ND	X

CAIRD, Center for Anti-Infective Research and Development.

CAZ-AVI, ceftazidime-avibactam; CAZ, ceftazidime.

I⁻, neutropenic; I⁺, immunocompetent.

NA, not applicable.

ND, no data (isolates were characterized phenotypically only).

Derepressed, as judged by a qualitative phenotypic nitrocefin hydrolysis test.

OXA-9 but containing an in-frame termination codon.