TABLE 4.
Population parameter values after a single dose of 1.2 million units of benzathine penicillin G in adultsa
| Parameter | Unit of measure | Value |
|
|---|---|---|---|
| Mean (SD) | Median | ||
| Ke0 | 1/(day · 70 kg0.25) | 4.11 (2.22) | 3.96 |
| Ka | 1/day | 0.40 (0.25) | 0.32 |
| KCP0 | 1/(day · 70 kg0.25) | 6.91 (6.30) | 4.71 |
| KPC0 | 1/(day · 70 kg0.25) | 0.27 (0.34) | 0.12 |
| V0 | Liters/70 kg | 260.96 (96.45) | 239.43 |
| Calculated from full-fitted concn profiles | |||
| AUC0–∞ | mg · h/liter | 19.33 (6.09) | 18.68 |
| Clearance | Liters/h/kg | 0.68 (0.24) | 0.65 |
| Half-life of absorption | h | 72.55 (202.21) | 50.79 |
| Half-life of elimination | h | 6.03 (4.29) | 4.19 |
| Cmax | mg/liter | 0.14 (0.09) | 0.13 |
| Tmax | h | 22.90 (32.10) | 9.60 |
a
AUC0–∞, area under the concentration-time curve from 0 h to infinity; Ka, absorption from dosing to the central compartment; Ke, elimination from the central compartment; KCP, transfer from the central to the peripheral compartment; KPC, transfer from the peripheral to the central compartment; V, volume of the central compartment; Cmax, maximum concentration; Tmax, time to maximum concentration.