TABLE 1.

Proportions of individuals infected with wild-type and mutant P. falciparum or P. vivax genotypes^a

Sample type and gene	Codon(s)	Amino acid(s)b	% of individuals infected with mutant genotype from the indicated study arm			P valued
			Placebo	AQ-SP	ART-SP
P. falciparum
			n = 70	n = 59	n = 49
pfdhfr	51	Nc	100	100	100	NS
	59	C/R	1.4/98.6	1.7/98.3	0/100	NS
	108	S/N	1.4/98.6	1.7/98.3	0/100	NS
	164	Ic	100	100	100	NS
			n = 63	n = 51	n = 47
pfdhps	436–437	SA/SG	69.8/30.2	64.7/37.3	76.6/25.5	NS
	540	K/E	87.3/12.7	86.3/13.7	91.5/10.6	NS
	581	A/G	100/0	100/2.0	100/0	NS/NS
	613	A	100	100	100	NS
			n = 66	n = 55	n = 44
pfcrt	72–76	CVMNK/SVMNT/CVIET	1.5/98.5/0	3.6/96.4/1.8	4.5/100/0	NS
			n = 59	n = 44	n = 39
pfmdr1	86	N/Y	10.2/89.8	9.1/90.9	5.1/94.9	NS
	184	Y/F	93.2/6.8	100/0	100/0	NS
	1034	Sc	100	100	100	NS
	1042	N/D	96.6/3.4	100/0	100/0	NS
	1246	Dc	100	100	100	NS
P. vivax
			n = 177	n = 167	n = 205
pvdhfr	57/58/61	FST/FRT/LRT/LRM	15.3/11.3/41.8/66.1	18.0/7.2/47.9/60.5	16.6/7.8/46.3/56.1	NS
	117	S/N/T	51.4/9.6/74.6	55.7/6.0/68.9	52.2/6.8/66.3	NS
	173	Ic	100	100	100	NS
			n = 170	n = 160	n = 195
pvdhps	382–383	SC/SG/CC	98.8/3.5/0	98.1/1.9/0.6	98.5/3.1/0	NS
	553	A/G	100/0	100/0.6	100/0	NS/NS
	647	A/S/P	8.8/1.2/93.5	5.0/0/96.9	6.2/0.5/97.9	NS
			n = 173	n = 170	n = 211
pvmdr1	976	Y/F	46.2/74.0	54.1/72.9	46.0/74.4	NS

^an values represent the numbers of individuals in each group.

^bBoldface indicates mutant amino acids.

^cpfdhfr 51N and 164L, pfdhps 436–437FG and 613S, pfmdr1 1034C and 1246Y, and pvdhfr 173L genotypes were not observed.

^dNS, not significant.