TABLE 4.

Antitubercular activity of selected compounds in infected macrophages and toxicity of compounds for J774 macrophages^a

Compound	Log reduction (concn of compound [μM])b			% viability (concn of compound [μM])	SIc (IC50/IC90)
2	1.72 (2.74)	1.78 (27.4)	1.75 (274)	32 (274)	180
3	1.30 (1.94)	1.31 (19.4)	0.94 (194)	24 (194)	13
4	1.18 (1.88)	1.16 (18.8)	1.45 (188)	91 (188)	795
7	0.69 (2.44)	1.03 (24.4)	1.00 (244)	19 (244)	129
8	1.36 (1.94)	1.55 (19.4)	1.56 (194)	70 (194)	21
21	0.36 (2.79)	0.31 (27.9)	0.24 (279)	38 (279)	9
RMP	0.76 (0.122)	1.11 (1.22)	2.0 (12.2)	86 (12.2)	694

^aAll values are averages of duplicate measurements.

^bData are for three serial 10-fold dilutions of the indicated compound.

^cFor calculation of the selectivity index (SI), IC₉₀ values from Table 1 were used. In the case of compound 21, the LORA MIC from Table 2 was used.