TABLE 2.
Virologic and biochemical response during rescue therapy by genotypic resistance profile
| Outcome and time point | Value for group |
P value | ||
|---|---|---|---|---|
| LAM/ETV-R (n = 45) | LAM/ADV-R (n = 28) | LAM/ETV/ADV-R (n = 20) | ||
| Virologic | ||||
| Change in HBV DNA (log10 IU/ml)a | ||||
| 3 mo | −2.86 (−4.83 to 2.90) | −2.30 (−4.83 to −0.67) | −2.10 (−3.50 to −0.05) | 0.008 |
| 6 mo | −3.02 (−5.82 to 1.73) | −2.52 (−5.84 to −1.04) | −2.48 (−4.66 to −1.02) | 0.719 |
| 12 mo | −3.19 (−6.43 to −1.72) | −2.48 (−5.84 to −1.14) | −2.51 (−4.73 to −1.18) | 0.377 |
| Complete virologic suppression (undetectable HBV DNA)b | 0.072c | |||
| 3 mo | 31.1 (45) | 50.0 (28) | 30.0 (20) | |
| 6 mo | 55.7 (45) | 75.0 (28) | 65.0 (20) | |
| 9 mo | 58.1 (32) | 86.6 (23) | 88.3 (18) | |
| 12 mo | 67.8 (18) | 93.3 (19) | 88.3 (16) | |
| 24 mo | 82.8 (2) | NAd | 88.3 (2) | |
| Biochemical (normalization of serum ALT)b | 0.003c | |||
| 3 mo | 5.9 (17) | 50.0 (6) | 50.0 (6) | |
| 6 mo | 23.5 (17) | 50.0 (6) | 50.0 (6) | |
| 9 mo | 30.5 (15) | 83.3 (3) | 50.0 (6) | |
| 12 mo | 44.5 (11) | 100.0 (2) | 83.3 (6) | |
a
Data are medians, with ranges in parentheses.
b
Data are cumulative probabilities of the response at the indicated time points, based on the Kaplan-Meier method, with the number of patients under observation in parentheses.
c
The log rank test was used to compare the hazard rates among the groups.
d
NA, not applicable.