TABLE 3.
Univariate and multivariate analysis of the clinical factors predictive of complete virologic suppression during rescue therapy
| Variable | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Hazard ratioa | P valueb | Adjusted hazard ratio | P value | |
| Age (per yr) | 1.003 (0.978–1.028) | 0.843 | ||
| Baseline serum HBV DNA (per 1 log10 IU/ml) | 0.584 (0.489–0.697) | <0.001 | 0.565 (0.461–0.692) | <0.001 |
| Baseline serum ALT (per IU/liter) | 0.998 (0.994–1.002) | 0.262 | ||
| HBeAg (positive vs negative) | 0.700 (0.431–1.137) | 0.150 | ||
| Liver cirrhosis (positive vs negative)c | 1.082 (0.655–1.787) | 0.760 | ||
| Time point of rescue therapy | ||||
| Virologic breakthrough (yes vs no) | 0.747 (0.459–1.215) | 0.240 | ||
| Biochemical breakthrough (yes vs no) | 0.512 (0.298–0.879) | 0.015 | 1.238 (0.664–2.309) | 0.501 |
| Drug resistance | 0.078 | |||
| LAM/ETV-R vs LAM/ADV-R | 0.541 (0.316–0.924) | 0.024 | ||
| LAM/ETV-R vs LAM/ETV/ADV-R | 0.751 (0.414–1.362) | 0.345 | ||
| LAM/ADV-R vs LAM/ETV/ADV-R | 1.393 (0.751–2.584) | 0.294 | ||
a
Data in parentheses are 95% CIs.
b
P values were determined using Cox proportional hazards regression models. A P value of <0.05 indicates a significant difference.
c
Liver cirrhosis was diagnosed when the platelet count was below 100,000/mm3 and associated splenomegaly or esophageal-gastric varices were detected.