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Mean Cmax by dose of components of AVI-6002 (AVI-7537 [○] and AVI-7539 [□]) and AVI-6003 (AVI-7287 [+] and AVI-7288 [◇]). Linear regression analysis yielded R2 values of 0.96 for AVI-7537, 0.94 for AVI-7539, 0.96 for AVI-7287, and 1.00 for AVI-7288. The Cmax (ng/ml) slopes per mg/kg dose are 5,701 ± 568 for AVI-7537, 6,069 ± 780 for AVI-7539, 5,545 ± 534 for AVI-7287, and 6,122 ± 182 for AVI-7288. An individual linear regression line is plotted for each agent.
