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Mean AUC0–24 by dose of components of AVI-6002 (AVI-7537 [○] and AVI-7539 [□]) and AVI-6003 (AVI-7287 [+] and AVI-7288 [◇]). Linear regression analysis yielded R2 values of 0.99 for AVI-7537, 0.98 for AVI-7539, 0.99 for AVI-7287, and 1.00 for AVI-7288. The AUC0–24 (h·ng/ml) slopes per mg/kg dose are 8,095 ± 442 for AVI-7537, 8,612 ± 635 for AVI-7539, 7,961 ± 325 for AVI-7287, and 7,244 ± 154 for AVI-7288. An individual linear regression line is plotted for each agent.
