TABLE 1.
Study agents
| Parent compound | PMOplus component | Molecular mass (Da) | No. of nucleobases | Nucleobase composition (%) |
No. of piperazine rings | Target | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| A | C | G | I | T | ||||||
| AVI-6002 | AVI-7357 | 6,825.9 | 19 | 11 | 21 | 26 | 0 | 42 | 5 | Ebola viral protein 24, viral matrix protein that inhibits interferon signaling |
| AVI-7359 | 7,092.1 | 20 | 5 | 30 | 20 | 0 | 45 | 5 | Ebola viral protein 35, component of the RNA-dependent RNA polymerase that antagonizes the interferon pathway | |
| AVI-6003 | AVI-7287 | 7,491.4 | 21 | 14 | 24 | 14 | 10 | 38 | 6 | Marburg viral protein 24, viral matrix protein that inhibits interferon signaling |
| AVI-7288 | 8,179.0 | 23 | 43 | 17 | 13 | 4 | 22 | 5 | Marburg nucleoprotein, the major nucleoprotein involved in RNA encapsulation | |