TABLE 4.
PK parameters of components of AVI-6002 (AVI-7537 and AVI-7539) and AVI-6003 (AVI-7287 and AVI-7288)
| Component and dose (mg/kg) | Mean (SD) |
|||||
|---|---|---|---|---|---|---|
| Cmax (ng/ml) | AUC0–24 (h·ng/ml) | Tmax (h) | Plasma half-life (h) | CLP (ml/h/kg) | Vss (ml/kg) | |
| AVI-7537 | ||||||
| 0.005 | 185 (108) | 285 (173) | 0.5 (0.08) | 2.0 (0.30) | 31 (32.6) | 65 (68.2) |
| 0.05 | 425 (99) | 617 (237) | 0.5 (0.00) | 2.0 (0.57) | 89 (29.1) | 183 (23.8) |
| 0.5 | 3,360 (974) | 4,060 (462) | 0.5 (0.00) | 3.6 (0.25) | 122 (11.5) | 382 (139.0) |
| 1.5 | 6,460 (2,370) | 10,100 (2,140) | 0.5 (0.00) | 2.8 (0.81) | 152 (32.3) | 406 (124.0) |
| 3.0 | 20,900 (5,220) | 27,000 (6,520) | 0.5 (0.07) | 4.6 (1.17) | 114 (22.9) | 334 (42.6) |
| 4.5 | 24,100 (3,440) | 35,300 (3,700) | 0.5 (0.08) | 4.0 (0.71) | 126 (12.6) | 453 (70.8) |
| AVI-7539 | ||||||
| 0.005 | 242 (67) | 338 (72) | 0.5 (0.07) | 2.1 (0.09) | 15 (2.7) | 48 (40.3) |
| 0.05 | 399 (107) | 519 (150) | 0.5 (0.09) | 1.9 (0.63) | 103 (28.5) | 201 (13.8) |
| 0.5 | 3,480 (1,130) | 3,950 (658) | 0.5 (0.06) | 2.9 (0.80) | 127 (18.9) | 387 (125.0) |
| 1.5 | 7,910 (1,440) | 10,900 (1,950) | 0.5 (0.07) | 2.5 (0.92) | 140 (24.4) | 329 (91.2) |
| 3.0 | 24,000 (4,330) | 30,100 (6,250) | 0.5 (0.00) | 4.6 (1.21) | 101 (19.4) | 273 (38.6) |
| 4.5 | 24,800 (2,090) | 36,700 (2,420) | 0.6 (0.00) | 3.9 (1.01) | 121 (7.9) | 401 (35.1) |
| AVI-7287 | ||||||
| 0.005 | 34 (8) | 48 (11) | 0.6 (0.14) | 1.6 (0.92) | 94 (15.8) | 189 (99.8) |
| 0.05 | 313 (89) | 338 (65) | 0.5 (0.08) | 1.8 (0.26) | 151 (31.0) | 299 (65.3) |
| 0.5 | 2,550 (486) | 4,000 (729) | 0.5 (0.14) | 1.9 (0.46) | 129 (27.0) | 278 (33.9) |
| 1.5 | 11,000 (1,530) | 14,700 (3,470) | 0.5 (0.0) | 2.2 (0.33) | 105 (24.7) | 267 (50.4) |
| 3.0 | 20,100 (4,290) | 24,900 (3,200) | 0.5 (0.0) | 5.0 (2.04) | 120 (17.0) | 354 (88.9) |
| 4.5 | 23,300 (2,770) | 35,400 (3,720) | 0.4 (0.11) | 3.7 (1.46) | 123 (12.3) | 537 (169.0) |
| AVI-7288 | ||||||
| 0.005 | 36 (7) | 45 (7) | 0.4 (0.12) | 1.2 (0.48) | 104 (17.6) | 158 (21.0) |
| 0.05 | 272 (97) | 322 (105) | 0.5 (0.06) | 1.6 (0.19) | 171 (67.9) | 303 (142.0) |
| 0.5 | 2,660 (271) | 4,060 (638) | 0.5 (0.01) | 1.7 (0.46) | 126 (23.4) | 241 (30.5) |
| 1.5 | 8,210 (460) | 11,500 (1,680) | 0.5 (0.01) | 2.4 (0.53) | 133 (19.2) | 277 (38.4) |
| 3.0 | 19,300 (290) | 22,900 (1,170) | 0.5 (0.01) | 4.1 (1.95) | 130 (7.2) | 315 (131.0) |
| 4.5 | 26,900 (5,040) | 32,200 (3,480) | 0.5 (0.06) | 5.5 (2.51) | 136 (11.6) | 569 (298.0) |