TABLE 1.
PK parameters of GP-4 following a single i.v. administration of 3, 10, or 30 mg/kg GP-4 to male Sprague-Dawley ratsa
| Dose (mg/kg) | Cmax (ng/ml) | Terminal t1/2 (h) | AUC0–t (ng · h/ml) | AUC0–∞ (ng · h/ml) | CL (ml/min/kg) | V (ml/kg) |
|---|---|---|---|---|---|---|
| 3 | 1,430 ± 315 | 4.4 ± 1.4 | 722 ± 66.4 | 751 ± 77.4 | 68.0 ± 6.7 | 26,600 ± 9,295 |
| 10 | 7,310 ± 762 | 7.7 ± 1.2 | 3,490 ± 72.4 | 3,660 ± 99.3 | 45.6 ± 1.3 | 30,400 ± 4,768 |
| 30 | 13,600 ± 3,227 | 7.9 ± 0.7 | 11,400 ± 1,645 | 12,500 ± 1,813 | 42.1 ± 7.0 | 29,600 ± 7,736 |
a
Data are expressed as the means of 3 independent determinations ± standard errors.