FIG 6.

Aggregate structure allows for antibiotic resistance to tobramycin. (A) Planktonic bacterial survival when exposed to tobramycin (TOB; open bars) and tobramycin and DNase (hatched bars). (B) Survival of P. aeruginosa aggregates formed in the presence of neutrophil products and exposed to tobramycin (open bars) and tobramycin and DNase (hatched bars). Survival (%) was calculated by dividing the CFU of each treatment by the CFU of an untreated sample. The means ± standard errors of the means (SEM) are depicted from 8 independent experiments. Mann-Whitney t test between aggregates treated with tobramycin and those treated with tobramycin plus DNase. *, P < 0.05.